Spider-Man was premiered in the US on May 3rd, 2002.
One of the scenes presents Norman Osborn (played by Willem Dafoe) meeting the protagonist, Peter Parker (portrayed by Toby MacGuire).
The first case of the image macro showed up on 4chan on October 25th, 2016.
The format would appear on Reddit in 2017, first on the r/raimimemes subreddit, then on various other subreddits.
By the end of 2017, “I’m something of a scientist myself” would appear on sites like Imgur, Facebook, Tumblr as well as Instagram.