Meaning
What does You Like Krabby Patties Don’t You, Squidward mean?
You like Krabby Patties don’t you, Squidward refers to a memorable SpongeBob SquarePants quote, which is popularly used online as both a snowclone and an image macro format.
The image macros either depict SpongeBob or a completely different person, with a suspecting smile.
Origin
What's the origin of You Like Krabby Patties Don’t You, Squidward?
The quote originates from Season 3 Episode 3 of SpongeBob SquarePants, titled Just One Bite.
The episode was first aired in the United States on October 5th, 2001.
In one of the scenes the titular hero of the animated series poses the question to his neighbor, with a wide smile.
The first humorous video of the scene was uploaded to YouTube by user AveryandJordantv on July 21st, 2010, under the title “You like Krabby Patties, don’t you, Squidward”.
Spread & Usage
How did You Like Krabby Patties Don’t You, Squidward spread?
Throughout the 2010’s, the meme would appear on image macros, GIFs and videos, including parodies as well as earrape content.
“You like Krabby Patties don’t you, Squidward?” would grow popular on sites like YouTube, Reddit, Tumblr, 9GAG and Twitter.

External resources
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Encyclopedia SpongeBobia | Fandom – Just One Bite